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PMC may not survive
in its present form?

ISLAMABAD: Ever since its birth in emergency with lot of congenital malformations, the long term survival of Pakistan Medical Commissions in its present form remains questionable.

Its functioning has also been challenged in the Courts while its performance while conducting the MDCAT exam has come under severe criticism in the media by not only candidates desiring of getting admission to medical and dental colleges but by the medical profession as well. The National Licensing Examination has also become quite controversial. Though the objectives are noble but the methodology adopted for its implementation without taking the stake holders into confidence remains the main hurdle in its smooth functioning.


What Are the Effects of
Inappropriate Prescriptions
in Older Adults?

Individuals are often prescribed increasing numbers of medications as they age, and while many of these prescriptions are justifiable, some may be inappropriate. A recent analysis published in the British Journal of Clinical Pharmacology examined the results of all studies investigating associations between potentially inappropriate prescribing—which includes prescribing medications that may not produce benefits relative to harm and not prescribing medications that are recommended-and outcomes of older adults.

Potentially inappropriate prescribing was significantly associated with a range of health-related and system-related outcomes, including functional decline, falls, and hospital admissions due to drug-related side effects.

Several decision support tools for quality prescribing are available; however, our analysis highlights that medication-related harm due to inappropriate prescribing remains problematic, said lead author Alemayehu Mekonnen, PhD, of Deakin University, in Australia. A comprehensive assessment of medication use, especially during care transitions such as at hospital discharge, is an important task to reduce medication-related harm and associated healthcare costs.

https://onlinelibrary.wiley.com/doi/10.1111/bcp.14870


Study links cognitive
decline with both bone
loss and fracture risk

New research published in the Journal of Bone and Mineral Research has found that cognitive decline is linked with accelerated bone loss and an increased fracture risk in women. In the study of 1,741 women and 620 men aged a 65 years without dementia who were followed from 1997 through 2013, both genders experienced similar declines in cognitive function and bone mass.

After adjustments, cognitive decline was associated with bone loss in women but not men. Also, significant and clinical important cognitive decline in women was associated with a 1.7-fold higher risk of bone fractures over the subsequent 10 years.

Notably, the relationship between bone loss and cognitive decline was bidirectional with no evidence of one preceding the other. The relationship between cognitive decline, bone loss, and fracture risk in women may be driven by shared risk factors.

These findings may help refine clinical practices guidelines regarding how bone loss and cognitive decline can be monitored in older age, to ensure appropriate and effective treatment, said lead author Dana Bliuc, PhD, MD, of the Garvan Institute of Medical Research, in Australia. This is particularly important because both bone loss and cognitive decline are silent conditions that can go undetected for long periods of time, often until the conditions have severely progressed.

https://onlinelibrary.wiley.com/doi/10.1002/jbmr.4402

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