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Cancer & its treatment may
accelerate Aging process

A new study examines the effects of cancer and its treatment on the aging process. Investigators found that expression of a gene associated with aging is higher in young patients with cancer after treatment with chemotherapy and in young cancer survivors who are frail. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).

Previous research has shown that a protein called p16INK4a, which slows cell division, is produced at higher levels by cells as a person ages. Using expression of the gene that codes for p16INK4a as a marker of age, Andrew Smitherman, MD, MSc, of the University of North Carolina at Chapel Hill.s Lineberger Comprehensive Cancer Center, and his colleagues examined immune cells circulating in the blood of young adult survivors of childhood cancers and of children and adolescents newly diagnosed with cancer.

The team first analyzed cells from 60 survivors and compared them with cells from 29 age-matched individuals without a history of cancer. Expression of the gene that codes for p16INK4a was higher in survivors than in controls, representing a 25-year age acceleration. Nine survivors were frail, and they had a higher level of expression compared with survivors who were not frail, representing a 35-year age acceleration. The researchers also found that in the nine children and adolescents in the study who had a new diagnosis of cancer, expression was higher after treatment with chemotherapy than before treatment. Higher expression of p16INK4a in peripheral blood lymphocytes has been described in older adults following chemotherapy, but prior to this study, not in young adult survivors, said Dr. Smitherman. This study is important as we try to understand the biological mechanisms underlying the manifestations of early aging in this population.

Dr. Smitherman noted that elevated p16INK4a expression as a marker of aging may help identify cancer survivors at risk for developing frailty and functional disability. Additionally, expression of p16INK4a may prove useful as a measure to study treatments aimed at mitigating the early aging effects of cancer treatment, he said. (DOI: 10.1002/cncr.33112).

Sindh planning to have its
own Medical & Dental Council

KARACHI: The provincial government of Sindh is planning to have its own Medical & Dental Council to regulate undergraduate and postgraduate medical education as well as health services. This was stated by the Sindh Health Minister last week.

The Federal Government, it may be mentioned here has established the Pakistan Medical Commission disbanding the PM&DC and it has attracted lot of criticism from the medical profession. The future developments in this regard will be watched with interest by all the stake holders.

Prof. Waqar, Prof. 
Fayyaz Mustafa become 
victims of COVID19

KARACHI: COVID19 continues to take the lives of healthcare professionals treating these patients. The most recent victims of this pandemic include Prof. Syed Waqar Ahmad Registrar of College of Physicians & Surgeons Pakistan, Prof. Fayyaz Mustafa Prof. and Head of the Department of Medicine at Quaid-e-Azam Medical College Bahawalpur. Prof. Waqar passed away on Thursday October 22nd 2020. May God Almighty rest the departed souls in Jannah. Ameen.

Common Purposes of
Medical Journal Editors

The overarching purpose of medical journals (and thus of editors), regardless of language, region of the world or type of journal, should be to promote the science and art of medicine and the betterment of the public health. To achieve this purpose, key elements that editors consider include public health, science, ethics, economics, rigor, balance and breadth. Different journals and editors would have differing mixtures of these objectives and requirements according to their individual circumstances.

Specific critical objectives for medical journals include the following:

“To foster responsible and balanced debate on controversial issues and policies that affect medicine and health care.”

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