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Does a Mother’s Pre-Pregnancy
weight affect her children’s
future fertility?

A recent study published in Acta Obstetricia et Gynecologica Scandinavica found that sons born to mothers who fell within the overweight range were more likely to be diagnosed with infertility during adulthood than sons of mothers with normal-range weight. No association between maternal weight and infertility was seen in daughters.

In the Danish study of 9,232 adult sons and daughters, 9.4% of participants were infertile. The authors adjusted for several potential confounding factors and found that sons whose mothers had a body mass index over 25 kg/m2 before pregnancy had 1.4-times higher odds of infertility than sons whose mothers had a body mass index of 18.5 to 24.9 kg/m2.
Approximately 12.5% of couples are affected by infertility, which is often defined as unsuccessfully attempting to conceive for a year or longer. Overall, one-third of couples infertility cases are caused by male reproductive issues, one-third by female reproductive issues, and one-third is either a combination or due to unknown factors.

Infertility is a global public health issue, and it is important that research focus on addressing risk factors, said lead author Linn Arendt, MD, PhD, a postdoc at Aarhus University and Aarhus University Hospital. We know that children born to mothers in the overweight or obesity weight range face higher risks of several adverse outcomes, both in the short and long term. These findings add to evidence that weight during pregnancy may also affect male future reproductive health; however, the findings need to be corroborated in future studies.


PSIM launches its official
journal with great funfair

LAHORE: Pakistan Society of Internal Medicine (PSIM) formally launched its official publication Journal of Pakistan Society of Internal Medicine with great funfair at the Governor House Lahore where Governor of Punjab was the Chief Guest. Punjab Minister for Higher Education and Provincial Health Secretary was also resent. The meeting was also attended by a large number of eminent faculty members from various medical intuitions and executive of PSIM besides members of its Editorial Board.

Speaking at the occasion Governor of Punjab and the Minister of Higher Education both commended the efforts of PSIM, its academic activities specially the start of its official journal copies of which were distributed among the participants. Chaudhry Sarwar also commended the performance of the healthcare professionals during the Covid19 pandemic.

President PSIM and Vice Chancellor of University of Health Sciences Prof. Javed Akram in his address highlighted the importance of quality research and having good quality standard Impact Factor Journals where this research could be published. At present Pakistan has just three medical journals which enjoy Impact Factor and we need to increase this number. He also referred to the professional capacity building measures for the Editors of medical journals by starting a Certificate Course in Medical Editing at UHS which will be transformed into Masters Programme in Health Journalism in the days to come. JPSIM he hoped will strive for getting international recognition, Impact Factor for which the Editorial Board are working hard.

Dr. Somia Iqtidar highlighted the academic activities of the PSIM ever since its inception two years ago. A video entitled “The Human Connection” was also screened on this occasion. Prof. Azizur Rehman Editor of JPSIM gave details of Editorial Board Members. The meeting was conducted by Prof. Aftab Mohsin and it was also addressed by Prof. Balqis Shabbir.

Regular timely publication of a peer reviewed quality journals is not an easy but a very stressful and frustrating job in view of the lack of good quality manuscripts, non-availability of the good quality reviewers and numerous other constraints. Indexing in major databases and getting an Impact Factor also takes a few years and only time will tell how serious the PSIM is and how much time its Editorial Board members can devote to this publication.

Hydroxychloroquine Blood
Levels Predict Clotting Risk
in Patients with Lupus

The antimalarial drug hydroxychloroquine is frequently prescribed to treat symptoms of the autoimmune disease lupus. In addition to decreasing disease flares, the drug can also prevent blood clots, which are a major problem in individuals with lupus. A new study in Arthritis & Rheumatology shows that monitoring patients blood levels of hydroxychloroquine can predict their clotting risk.

In 739 patients, clotting occurred in 38 patients (5.1%). Average hydroxychloroquine blood levels were lower in patients who developed clots, and clotting rates were reduced by 12% for every 200 ng/mL increase in the most recent hydroxychloroquine blood level.

The finding may help clinicians determine the optimal dosing of hydroxychloroquine in patients with lupus.Hydroxychloroquine blood levels can be used to monitor adherence, benefits, and risks in lupus, said lead author Michelle Petri, MD, MPH, of the Johns Hopkins University School of Medicine.


Screening tool may help
diagnose mental disorders

in Early Pregnancy

A recent study published in Acta Obstetricia et Gynecologica Scandinavica found that questions typically asked to new mothers to screen for depression after giving birth can also help to detect depressive symptoms and other mental disorders during early pregnancy.

The questions are part of what’s called the Edinburgh Postnatal Depression Scale. In the study of 2,271 women, 85% of women with a score of 13 or higher had one or more mental disorders or risk factors for mental disorders during early pregnancy.

The Edinburgh Postnatal Depression Scale seems to be a valuable screening tool to detect depressive symptoms as well as other mental disorders during early pregnancy, the authors wrote.


The important role of Pharmacists
for Older Adults Health

Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the British Journal of Clinical Pharmacology.

In the study of patients aged 65 years and older who came to a pharmacist-led outpatient clinic at a general hospital in Beijing, China between 2016 and 2018, pharmacists were helpful not only for identifying and solving drug-related problems, but also for improving measures such as blood pressure and cholesterol, and for reducing the cost of medications for patients.

To the best of our knowledge, this study was the first to evaluate the outcomes of pharmacist-led medication therapy management services in ambulatory elderly patients in mainland China, the authors wrote.


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