New treatments for chronic
inflammatory pain

New research uncovers a cascade of reactions within nerve cells that relay sensations of pain associated with inflammation. The findings, which are published in the British Journal of Pharmacology, indicate that drugs designed to curb this pathway may help relieve inflammatory pain in sufferers.

Previous studies identified that a molecule called Rac1 maintains chronic neuropathic pain resulting from injury to the nervous system. Jun Chen, MD, PhD, of the Fourth Military Medical University in China, and his colleagues wondered if Rac1 might also be involved with chronic inflammatory pain, which is caused by tissue injury, trauma, and diseases such as arthritis. An estimated 20 percent of people worldwide suffer with chronic pain. with the majority of cases being inflammatory pain.

“We found that Rac1 can be activated in chronic inflammatory pain and drugs that curb this reaction can relieve pain, offering the promise of new drugs for pain treatment in the clinic,” said Dr. Chen.

These findings were based on experiments involving rats: when investigators injected the paws of rats with bee venom to cause inflammation, Rac1 was activated and set off a cascade of reactions involved in pain perception. In contrast, giving the rodents a molecule that inhibits Rac1 (called NSC23766) before or after the bee venom injection reduced their paw flinches and their pain hypersensitivity. All studies involving animals were reported in accordance with a set of guidelines referred to as ARRIVE (Animals in Research: Reporting In Vivo Experiments). (PR)

HEC Inspection Team visits
Baqai Medical University

KARACHI: An inspection team of Higher Education Commission (HEC), Government of Pakistan visited Baqai Medical University. It comprised of senior members including Dr. Zahoor Ahmed Bazai (Director, QEC & Faculty Training & Development Center, University of Balochistan, Quetta), Dr. Nelofer Jamil (Director QEC &Chairperson, Environmental Sciences Department, Sardar Bahadur Khan Women’s University, Quetta) and Dr. Hanif-Ur-Rahman, QEC Department, University of Turbat).

The visit of HEC team was organized on the directives of Prime Minister’s initiative to review all the SOP’s & TOR’s in Pakistani Universities.On arrival at the Varsity, BMU Chancellor Prof. Dr. Fareeduddin Baqai, Vice Chancellor Prof. Dr. Zahida Baqai, Pro- VC Major General (Retd.) Dr. Muhammad Aslam, Principals of Baqai Medical and Dental Colleges Prof. Dr. Iftekhar Ahmed and Prof. Dr. Kashif Ikram welcomed the delegation. BMU Director of Quality Enhancement Cell Lt. Col. (Retd.) Dr. Shahida Nagi, Director of Finance Aalijah Yousuf were also present on the occasion.After welcome address by Vice Chancellor Prof. Zahida Baqai,QEC Director Dr. Shahida Nagi gave a detailed presentation highlighting all important academic, research and administrative aspects of the university. She also presented overview of BMU’s community outreach & development programs underlining Varsity’s achievements in postgraduate studies and research. Dr. Nagi also apprised the visiting delegation of various curricular and extra-curricular activities taking place in the University.The visitors were also given details about various ongoing scholarship programs as well as research grants secured by BMU faculty members from Pakistan and abroad.

While praising BAQAIS for their resilience and dedication to strengthening the field of Medical Sciences in Pakistan, Dr. Zahoor Ahmedsaid the BMU should be commended for promoting a culture of inquisition and higher education in Pakistan. He further stated that adequate funding and appropriate infrastructure greatly enhances prospects for socio-economic growth of a society.The HEC team also inspected different departments, constituent institutes of the University and enquired about the available facilities.(PR)

World Epilepsy Day
commemorated at BMU

KARACHI: The World Epilepsy Day was commemorated at Baqai Medical University under the department of medicine / neurology. The meeting was chaired by Prof. Jameel Ahmad, Head f the Dept. of Medicine at BMU. While speaking on the occasion, Prof. Arif Herekar, chairman of the department of Neurosciences spoke on the various aspects i.e. what is epilepsy, its diagnosis and various treatment options available in Pakistan.

He further stated that though the first line antiepileptic drugs (AEDs) were freely available, they had more adverse effects than the newer AEDs. He also indicated that the second line AEDs though were more expensive but had fewer side effects and were more effective.

Infants and neonates with epilepsy must be diagnosed as early as possible. Infantile spasm (IS) if not diagnosed under 1 year of age, it could have very sinister consequences. It can easily evolve into a disease called Lennox Gastaut Syndrome (LGS) which happens to be untreatable. Healthcare professionals should not only be aware of the effects of the drug and their efficacy but they should also know their adverse effects. (PR)

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