Can early and high intravenous dose of Vitamin C prevent and treat COVID-19?

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Can early and high intravenous dose
of Vitamin C prevent and treat COVID-19?

High-dose intravenous vitamin C has also been successfully used in the treatment of 50 moderate to severe COVID-19 patients in China. The doses used varied between 10 g and 20 g per day, given over a period of 8–10 h. Additional Vitamin-C bolus may be required among patients in critical conditions. The oxygenation index was improving in real time and all the patients eventually cured and were discharged. In fact, high-dose Vitamin-C has been clinically used for several decades and a recent NIH expert panel document states clearly that this regimen (1.5 g/kg body weight) is safe and without major adverse events.

Because the development of efficacious vaccines and antiviral drugs takes time, Vitamin-C and other antioxidants are among currently available agents to mitigate COVID-19 associated ARDS. Given the fact that high-dose Vitamin-C is safe, healthcare professionals should take a close look at this opportunity. Obviously, well-designed clinical studies are absolutely needed to develop standard protocols for bedside use.

http://dx.doi.org/10.1016/j.medidd.2020.100028 Medicine in Drug Discovery
journal homepage: https://www.journals.elsevier .com/medicine-in-drug-discovery.

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