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Miracles of anti-inflammatory
enzymes in Gynaecology

Anti-inflammatory enzymes helps to subside the signs and symptoms of inflammation like swelling, redness, pain, loss of functions and hyperemia. The anti-inflammatory enzyme are most researched and marketed all over the world with the generic name of serratiopeptidase. The source is serratia E-15 protease which was originally isolated in the late 1960s from silk worm in Japan. It was first marketed by Takeda the name of Danzen DS. Its characteristic features include Proteolytic, Fibrinolytic, Anti-swelling & Anti-oedema. Danzen DS enhances the concentration of anti-biotics along with reduction in the pain by inhibiting the chemical mediators.

Photograph on left shows Dr. Shaila Anwar, Dr. Wasim Talib, and Dr. Ambreen Akhter of Lahore
Medical & Dental College with Dr. Aleem Shamsi during the Session on Miracles of Anti-inflammatory
Enzyme in Gynecology. On right Dr. Nusrat Shah and, Dr. Ambreen Bhutto of Gyn-1,
Civil Hospital Karachi with GPM, Mr. Naeem Akhtar and SPSS coordinator,
Mr. Salman Bashir in the SPSS workshop and Danzen DS presentation.

The Serum high molecular weight proteins are increased during inflammation. As a proteolytic agent it coverts them into small protein. Similarly the consistency of human milk is thickened during lactating period previously breast pumps & massage therapy were practiced as a solution for such inflammatory condition but nowadays health professionals are prescribing anti-inflammatory enzymes like Danzen DS post-operatively for wound healing like lateral episiotomy. It reduces breast engorgement as well as post-operative swelling.
This anti-inflammatory enzyme (serratiopeptidase) used thrice daily is effective therapeutic remedy for problems like breast engorgement, lateral or perineal laceration and post-operative swellings. During the post-inflammatory phase as the lymphocytes, phagocytes & collagen are increased similarly the fibroblast lay down excessive fibrin clots at the site of inflammation to prevent it spreading. This produces hematoma in the tissue and makes the local circulation in the adjacent area poor, causing the inflammatory reaction to prolong. It is therefore necessary to lyze and remove the fibrin. As a fibrinolytic this agent accelerates the elimination of pus and hematoma by breaking down fibrin clots. The pathological cysts which are formed commonly due to chronic infections have a clear demarcation of inflamed outer membrane.
The inflammatory exudates is common with infections which may cause severe swelling and edema involving the lymph nodes. As anti-tumificient, Danzen DS helps to subside the swelling and edema. It also helps to remove the necrotic tissue debris and dead cells from the site of infection by breaking high molecular weight inflammatory exudate into smaller amino acid that are positively utilized by the body.
High molecular weight Polypeptides or chemical mediators that induces pain like bradykinin, kallikrein & Kallidin are increased in the phase of inflammation. This anti-inflammatory enzyme (serratiopeptidase) inhibits the formation of these pain inducing amines. (PR)


 Spinal procedures benefit 
from Medical Innovations

LONDON, UK (GlobalData): Back problems are fast becoming a global epidemic, as aging populations, obesity, and conditions such as cancer or osteoporosis lead many individuals to injure their spines, and develop Vertebral Compression Fractures (VCFs), states a new report by healthcare experts GlobalData.

Vertebroplasty and vertebral augmentation consist of the insertion of bone cement into fractured vertebrae using a special needle. The new report* states that these treatments are likely to become more popular over coming years, due to the launch of new technologies.Vertebroplasty device manufacturers have launched new devices which offer more precise bone cement delivery techniques, reducing the probability of bone cement leakage and subsequent fracture among patients.
In addition to better delivery mechanisms, the vertebroplasty manufacturers are also exploring opportunities to develop alternatives to poly(methyl methaacrylate) (PMMA), which is currently used as bone cement in most of the procedures. PMMA used commonly in both vertebroplasty and vertebral augmentation has a tendency to leak from the crevices, particularly in vertebroplasty procedures. This results in increased risk of subsequent fractures as well as contributing to pain.
To counter this problem, vertebroplasty device manufacturers are exploring various alternatives to PMMA such as bio-ceramic bone cement, composite resin cement (such as Cortoss by Orthovita), calcium phosphate and calcium sulfate cement, carbonated hydroxyapatite cement, partially absorbable bone cement (Cerament by BoneSupport) and so on. New PMMA formulations are also explored as an alternative. These new filler materials have the potential to show better biocompatibility, biomechanical strength and radiopacity (for fluoroscopic guided procedures) than previously used PMMA formulations.
The global vertebral augmentation and vertebroplasty devices market was valued at $981.8m in 2011 and is forecast to grow at Compound Annual Growth Rate (CAGR) of 12.6% in the 2011–2018 period. (PR)



Prof. Zahida Baqai VC BMU presenting a mementoe to Dr. Fayaz Ahmed Ranjha
DG National Talent Pool Ministry of Education during his recent visit to
Baqai Medical University.

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