Update on tizanidine for muscle
spasticity andemerging indications

Gerard Malanga , Raymond D Reiter & Edward Garay
Overlook Pain Center, Associates in Rehabilitation Medicine, Summit, NJ, USA

Background: Tizanidine hydrochloride, an α 2 -adrenergic receptor agonist, isa widely used medication for the treatment of muscle spasticity. Clinical studies have supported its use in the management of spasticity caused by multiple sclerosis (MS), acquired brain injury or spinal cord injury. It has also been shown to be clinically effective in the management of pain syndromes, such as: myofascial pain, lower back pain and trigeminal neuralgia. This review summarizes the recent findings on the clinical application of tizanidine.

Objective: Our objective was to review and summarize the medical literature regarding the evidence for the usefulness of tizanidine in the management of spasticity and in pain syndromes such as myofascialpain.

Methods: We reviewed the current medical and pharmacology literature through various internet literature searches. This informationwas then synthesized and presented in paragraph and table form.

Results/conclusion: Tizanidine hydrochloride is a very useful medication in patients suffering from spasticity caused by MS, acquired brain injury or spinal cord injury. It can also be helpful in patients suffering from chronic neck and/or lower back pain who have a myofascial component to their pain. Doses should be started at low dose and gradually titrated to effect.

Keywords: Myofascialpain, Pain management, Spasticity, Tizanidine.
Expert Opin.Pharmacother. (2008) 9(12):2209-2215

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