Medical textbook authors received £11m in undisclosed payments from drug and device makers


 Payment to Textbook authors

Medical textbook authors received
£11m in undisclosed payments from
drug and device makers

Nigel Hawkes

Medical textbooks widely used by students and young doctors are riddled with undeclared conflicts of interest, a study has found. While virtually every leading medical journal now requires authors to declare any potential conflicts of interest, the same rules do not apply to textbooks widely used in the US, says a team from Bowdoin College in Brunswick, Maine, in findings published in AJOB Empirical Bioethics.1

The most striking example is Harrison’s Principles of Internal Medicine, now in its 20th edition. By searching a database of payments made to US doctors by 17 drug companies (ProPublic’s Dollars for Docs), the team found that contributors to the widely used textbook had received more than $11m (£7.9m; €8.9m) between 2009 and 2013 from drug and device manufacturers, none of it disclosed.

One contributor, identified as a male physician, received $856€‰067 over the period, the great majority being for research. Four of the top 10 recipients were oncologists, two were neurologists, and two endocrinologists. A second search showed that contributors to Harrison’s were often patent holders, an interest that also went undeclared. A separate analysis for 2014 showed that one contributor had received $560€‰021 over a 17 month period, 90% of it for consulting and the rest for travel. He also held four patents. Seven of the top 10 earners in 2014 were men.

The study limited itself to textbooks published in the US and to doctor’s resident there, as the data source does not include payments to doctors overseas. The other textbooks the study looked at are less well known and include books on pharmacology, osteopathy, applied therapeutics, and dentistry. The payments to contributor’s to Harrisons far exceeded those to authors of the other books examined.

The study’s authors, led by Brian Piper, said that they wanted to discover whether more than 1000 contributors to the textbooks had patents or received payments sufficient to warrant disclosure. The answer is clearly in the affirmative, they said.

Setting the results in context, they pointed out that earlier studies had shown that more than half the contributors to guidelines on cardiology had conflicts of interest and that three quarters of US physicians in cardiology or neurosurgery also had conflicts. Payments should not be used to stigmatize recipients, but they urged that full transparency should become a standard practice among the authors of biomedical educational materials.

Talking to the US health news website STAT, Piper said that after six years of doing this kind of study he was not surprised by the findings. However, we continue to be surprised that the publishers and authors of medical textbooks do not have the same transparency standards about conflicts of interest that have become widely accepted for clinical trials and other primary sources, he said.2

McGraw-Hill, publisher of Harrison’s, did not respond to STAT’s request for comment.


  1. Piper BJ, Lambert DA, Keefe RC, Smukler PU, Selemon NA, Duperry ZR.  Undisclosed conflicts of interest among biomedical textbook authors. AJOB Empir Bioeth2018. doi:10.1080/23294515.2018.1436095. pmid:29400625
  2. Marcus A, Oransky I. Authors of premier medical textbook didn’t disclose $11 million in industry payments. STAT Mar 2018.  Google Scholar BMJ 2018; 360 doi: (Published 08 March 2018) Cite this as: BMJ 2018;360:k1118
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